Expression of Estrogen Receptor 1 across Vanderbilt Subtypes of Triple Negative Breast Cancer

by Michaela Strizencova and Phung Tran 

Abstract 

Triple Negative Breast Cancer (TNBC) is a form of breast cancer that is characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor 2. The lack of receptors makes TNBC particularly difficult to treat, as typical breast cancer treatments often target these receptors via hormone-based therapies and drugs. Therefore, other methods must be explored in order to implement effective treatment for TNBC. One method utilizes the analysis and classification of various forms of TNBC; this research will explore the Vanderbilt subtypes, a TNBC classification method which allows for a deeper understanding of the disease and subsequently more specialized treatments for each unique case. The Gene Expression Omnibus is used to analyze the Vanderbilt subtypes, specifically examining the variation of estrogen receptor expression levels across the subtypes. 

Read the full report here.